Hematology Williams 7º Ed.
Hematology Williams 7º Ed.
Formato: PDF
Tamaño: 58.8 MB
Idioma: Ingles
Contenido:
Part I. Clinical Evaluation of the Patient
Chapter 1. Initial Approach to the Patient: History and Physical Examination
Chapter 2. Examination of the Blood
Chapter 3. Examination of the Marrow
Chapter 1. Initial Approach to the Patient: History and Physical Examination
Chapter 2. Examination of the Blood
Chapter 3. Examination of the Marrow
Part II. General Hematology
Chapter 4. Structure of the Marrow and the Hematopoietic Microenvironment
Chapter 5. The Lymphoid Tissues
Chapter 6. Hematology of the Newborn
Chapter 7. Hematology during Pregnancy
Chapter 8. Hematology in Older Persons
Chapter 4. Structure of the Marrow and the Hematopoietic Microenvironment
Chapter 5. The Lymphoid Tissues
Chapter 6. Hematology of the Newborn
Chapter 7. Hematology during Pregnancy
Chapter 8. Hematology in Older Persons
Part III. Molecular and Cellular Hematology
Chapter 9. Genetic Principles and Molecular Biology
Chapter 10. Cytogenetics and Gene Rearrangement
Chapter 11. Apoptosis
Chapter 12. Cell Cycle Regulation and Hematologic DisordersChapter 13. Signal Transduction Pathways
Chapter 14. The Cluster of Differentiation (CD) Antigens
Chapter 15. Hematopoietic Stem Cells, Progenitors, and Cytokines
Chapter 16. The Inflammatory Response
Chapter 17. Innate Immunity
Chapter 18. Dendritic Cells and the Control of Innate and Adaptive Immunity
Part IV. Therapeutic Principles
Chapter 19. Pharmacology and Toxicity of Antineoplastic Drugs
Chapter 20. Treatment of Infections in the Immunocompromised Host
Chapter 21. Principles of Antithrombotic Therapy
Chapter 22. Principles of Hematopoietic Cell Transplantation
Chapter 23. Principles of Immune Cell Therapy
Chapter 24. Principles of Vaccine Therapy
Chapter 25. Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications
Chapter 26. Principles of Gene Transfer for Therapy
Chapter 27. Pain Management
Part V. The Erythrocyte
Chapter 28. Morphology of the Erythron
Chapter 29. Composition of the Erythrocyte
Chapter 30. Production of Erythrocytes
Chapter 31. Destruction of Erythrocytes
Chapter 32. Clinical Manifestations and Classification of Erythrocyte Disorders
Chapter 33. Aplastic Anemia
Chapter 34. Pure Red Cell Aplasia
Chapter 35. Anemia of Chronic Renal Failure
Chapter 36. Anemia of Endocrine Disorders
Chapter 37. The Congenital Dyserythropoietic Anemias
Chapter 38. Paroxysmal Nocturnal Hemoglobinuria
Chapter 39. Folate, Cobalamin, and Megaloblastic Anemias
Chapter 40. Disorders of Iron Metabolism
Chapter 41. Anemia Resulting from Other Nutritional Deficiencies
Chapter 42. Anemia Associated with Marrow Infiltration
Chapter 43. Anemia of Chronic Disease
Chapter 44. Disorders of the Red Blood Cell Membrane: Hereditary Spherocytosis, Elliptocytosis, and Related Disorders
Chapter 45. Disorders of Red Cells Resulting from Enzyme Abnormalities
Chapter 46. Disorders of Globin Synthesis: The Thalassemias
Chapter 47. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities
Chapter 48. Methemoglobinemia and Other Causes of Cyanosis
Chapter 49. Hemolytic Anemia Resulting from Physical Injury to Red Cells
Chapter 50. Hemolytic Anemia Resulting from Chemical and Physical Agents
Chapter 51. Hemolytic Anemia Resulting from Infections with Microorganisms
Chapter 52. Hemolytic Anemia Resulting from Immune Injury
Chapter 53. Alloimmune Hemolytic Disease of the Newborn
Chapter 54. Acute Blood Loss Anemia
Chapter 55. Hypersplenism and Hyposplenism
Chapter 56. Primary and Secondary Polycythemias (Erythrocytosis)
Chapter 57. The Hematologic Aspects of Porphyria
Chapter 58. Hereditary and Acquired Sideroblastic Anemias
Part VI. Neutrophils, Eosinophils, Basophils, and Mast Cells
Chapter 59. Morphology of Neutrophils, Eosinophils, and Basophils
Chapter 60. Composition of Neutrophils
Chapter 61. Production, Distribution, and Fate of Neutrophils
Chapter 62. Eosinophils and Their Disorders
Chapter 63. Basophils and Mast Cells and Their Disorders
Chapter 64. Classification and Clinical Manifestations of Neutrophil Disorders
Chapter 65. Neutropenia and Neutrophilia
Chapter 66. Disorders of Neutrophil Function
Part VII. Monocytes and Macrophages
Chapter 67. Morphology of Monocytes and Macrophages
Chapter 68. Biochemistry and Function of Monocytes and Macrophages
Chapter 69. Production, Distribution, and Fate of Monocytes and Macrophages
Chapter 70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages
Chapter 71. Monocytosis and Monocytopenia
Chapter 72. Inflammatory and Malignant Histiocytosis
Chapter 73. Lipid Storage Diseases
Part VIII. Lymphocytes and Plasma Cells
Chapter 74. Morphology of Lymphocytes and Plasma Cells
Chapter 75. Composition and Biochemistry of Lymphocytes and Plasma Cells
Chapter 76. Lymphopoiesis
Chapter 77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production
Chapter 78. Functions of T Lymphocytes: T Cell Receptors for Antigen
Chapter 79. Functions of Natural Killer Cells
Chapter 80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders
Chapter 81. Lymphocytosis and Lymphocytopenia
Chapter 82. Immunodeficiency Diseases
Chapter 83. Hematologic Aspects of Human Immunodeficiency Syndrome
Chapter 84. Mononucleosis Syndromes
Part IX. Malignant Diseases
Chapter 85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders
Chapter 86. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Leukemia)
Chapter 87. Acute Myelogenous Leukemia
Chapter 88. Chronic Myelogenous Leukemia and Related Disorders
Chapter 89. Idiopathic Myelofibrosis (Myelofibrosis with Myeloid Metaplasia)
Chapter 90. Classification of Malignant Lymphoid Disorders
Chapter 91. Acute Lymphoblastic Leukemia
Chapter 92. Chronic Lymphocytic Leukemia and Related Diseases
Chapter 93. Hairy Cell Leukemia
Chapter 94. Large Granular Lymphocytic Leukemia
Chapter 95. Pathology of Lymphomas
Chapter 96. The Non-Hodgkin Lymphomas
Chapter 97. Hodgkin Lymphoma
Chapter 98. Plasma Cell Neoplasms: General Considerations
Chapter 99. Essential Monoclonal Gammopathies
Chapter 100. Plasma Cell Myeloma
Chapter 101. The Amyloidoses
Chapter 102. Macroglobulinemia
Chapter 103. Heavy-Chain Diseases
Part X. Hemostasis and Thrombosis
Chapter 104. Megakaryopoiesis and Thrombopoiesis
Chapter 105. Platelet Morphology, Biochemistry, and Function
Chapter 106. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis
Chapter 107. Control of Coagulation Reactions
Chapter 108. Vascular Function in Hemostasis
Chapter 109. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis
Chapter 110. Thrombocytopenia
Chapter 111. Essential Thrombocythemia and Thrombocytosis
Chapter 112. Hereditary Qualitative Platelet Disorders
Chapter 113. Acquired Qualitative Platelet Disorders
Chapter 114. The Vascular Purpuras
Chapter 115. Hemophilia A and Hemophilia B
Chapter 116. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors
Chapter 117. Hereditary Fibrinogen Abnormalities
Chapter 118. von Willebrand Disease
Chapter 119. Antibody-Mediated Coagulation Factor Deficiencies
Chapter 120. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation
Chapter 121. Disseminated Intravascular Coagulation
Chapter 122. Hereditary Thrombophilia
Chapter 123. The Antiphospholipid Syndrome
Chapter 124. Antibody-Mediated Thrombotic Disorders: Idiopathic Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia
Chapter 125. Venous Thrombosis
Chapter 126. Atherothrombosis: Disease Initiation, Progression, and Treatment
Chapter 127. Fibrinolysis and Thrombolysis
Part XI. Transfusion Medicine
Chapter 128. Erythrocyte Antigens and Antibodies
Chapter 129. Human Leukocyte and Platelet Antigens
Chapter 130. Blood Procurement and Screening
Chapter 131. Preservation and Clinical Use of Erythrocytes and Whole Blood
Chapter 132. Preservation and Clinical Use of Platelets
Appendix 1: SI Unit Conversion Table
Color Atlas I: Red Cell Morphology
Color Atlas II: Red Cell Morphology
Color Atlas III: Red Cell Morphology
Color Atlas IV: Red Cell Morphology
Color Atlas V: Normal Erythropoiesis
Color Atlas VI: Megaloblastic Erythropoiesis
Color Atlas VII: Granulocyte and Monocyte Morphology
Color Atlas VIII: Granulocyte Morphology
Color Atlas IX: Macrophages
Color Atlas X: Normal Neutrophilopoiesis
Color Atlas XI: Normal Megakaryocytopoieis
Color Atlas XII: Abnormal Megakaryocytopoieis and Platelets
Color Atlas XIII: Normal and Abnormal Platelets
Color Atlas XIV: Marrow Sections
Color Atlas XV: Non-Hematopoietic Cells in Marrow
Color Atlas XVI: Acute Myelogenous Leukemia
Color Atlas XVII: Acute Myelogenous Leukemia
Color Atlas XVIII: Myelodysplasia
Color Atlas XIX: Chronic Myelogenous Leukemia
Color Atlas XX: Lymphocytes and Acute and Chronic Lymphocytic Leukemia
Color Atlas XXI: Plasma Cells and Myeloma
Color Atlas XXII: Lymph Node Biopsies
Color Atlas XXIII: Fluorescence In Situ Hybridization (FISH) for Cytogenetic Analysis
Color Atlas XXIV: Parasites in the Blood
Color Atlas XXV: Cutaneous Lesions
Chapter 9. Genetic Principles and Molecular Biology
Chapter 10. Cytogenetics and Gene Rearrangement
Chapter 11. Apoptosis
Chapter 12. Cell Cycle Regulation and Hematologic DisordersChapter 13. Signal Transduction Pathways
Chapter 14. The Cluster of Differentiation (CD) Antigens
Chapter 15. Hematopoietic Stem Cells, Progenitors, and Cytokines
Chapter 16. The Inflammatory Response
Chapter 17. Innate Immunity
Chapter 18. Dendritic Cells and the Control of Innate and Adaptive Immunity
Part IV. Therapeutic Principles
Chapter 19. Pharmacology and Toxicity of Antineoplastic Drugs
Chapter 20. Treatment of Infections in the Immunocompromised Host
Chapter 21. Principles of Antithrombotic Therapy
Chapter 22. Principles of Hematopoietic Cell Transplantation
Chapter 23. Principles of Immune Cell Therapy
Chapter 24. Principles of Vaccine Therapy
Chapter 25. Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications
Chapter 26. Principles of Gene Transfer for Therapy
Chapter 27. Pain Management
Part V. The Erythrocyte
Chapter 28. Morphology of the Erythron
Chapter 29. Composition of the Erythrocyte
Chapter 30. Production of Erythrocytes
Chapter 31. Destruction of Erythrocytes
Chapter 32. Clinical Manifestations and Classification of Erythrocyte Disorders
Chapter 33. Aplastic Anemia
Chapter 34. Pure Red Cell Aplasia
Chapter 35. Anemia of Chronic Renal Failure
Chapter 36. Anemia of Endocrine Disorders
Chapter 37. The Congenital Dyserythropoietic Anemias
Chapter 38. Paroxysmal Nocturnal Hemoglobinuria
Chapter 39. Folate, Cobalamin, and Megaloblastic Anemias
Chapter 40. Disorders of Iron Metabolism
Chapter 41. Anemia Resulting from Other Nutritional Deficiencies
Chapter 42. Anemia Associated with Marrow Infiltration
Chapter 43. Anemia of Chronic Disease
Chapter 44. Disorders of the Red Blood Cell Membrane: Hereditary Spherocytosis, Elliptocytosis, and Related Disorders
Chapter 45. Disorders of Red Cells Resulting from Enzyme Abnormalities
Chapter 46. Disorders of Globin Synthesis: The Thalassemias
Chapter 47. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities
Chapter 48. Methemoglobinemia and Other Causes of Cyanosis
Chapter 49. Hemolytic Anemia Resulting from Physical Injury to Red Cells
Chapter 50. Hemolytic Anemia Resulting from Chemical and Physical Agents
Chapter 51. Hemolytic Anemia Resulting from Infections with Microorganisms
Chapter 52. Hemolytic Anemia Resulting from Immune Injury
Chapter 53. Alloimmune Hemolytic Disease of the Newborn
Chapter 54. Acute Blood Loss Anemia
Chapter 55. Hypersplenism and Hyposplenism
Chapter 56. Primary and Secondary Polycythemias (Erythrocytosis)
Chapter 57. The Hematologic Aspects of Porphyria
Chapter 58. Hereditary and Acquired Sideroblastic Anemias
Part VI. Neutrophils, Eosinophils, Basophils, and Mast Cells
Chapter 59. Morphology of Neutrophils, Eosinophils, and Basophils
Chapter 60. Composition of Neutrophils
Chapter 61. Production, Distribution, and Fate of Neutrophils
Chapter 62. Eosinophils and Their Disorders
Chapter 63. Basophils and Mast Cells and Their Disorders
Chapter 64. Classification and Clinical Manifestations of Neutrophil Disorders
Chapter 65. Neutropenia and Neutrophilia
Chapter 66. Disorders of Neutrophil Function
Part VII. Monocytes and Macrophages
Chapter 67. Morphology of Monocytes and Macrophages
Chapter 68. Biochemistry and Function of Monocytes and Macrophages
Chapter 69. Production, Distribution, and Fate of Monocytes and Macrophages
Chapter 70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages
Chapter 71. Monocytosis and Monocytopenia
Chapter 72. Inflammatory and Malignant Histiocytosis
Chapter 73. Lipid Storage Diseases
Part VIII. Lymphocytes and Plasma Cells
Chapter 74. Morphology of Lymphocytes and Plasma Cells
Chapter 75. Composition and Biochemistry of Lymphocytes and Plasma Cells
Chapter 76. Lymphopoiesis
Chapter 77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production
Chapter 78. Functions of T Lymphocytes: T Cell Receptors for Antigen
Chapter 79. Functions of Natural Killer Cells
Chapter 80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders
Chapter 81. Lymphocytosis and Lymphocytopenia
Chapter 82. Immunodeficiency Diseases
Chapter 83. Hematologic Aspects of Human Immunodeficiency Syndrome
Chapter 84. Mononucleosis Syndromes
Part IX. Malignant Diseases
Chapter 85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders
Chapter 86. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Leukemia)
Chapter 87. Acute Myelogenous Leukemia
Chapter 88. Chronic Myelogenous Leukemia and Related Disorders
Chapter 89. Idiopathic Myelofibrosis (Myelofibrosis with Myeloid Metaplasia)
Chapter 90. Classification of Malignant Lymphoid Disorders
Chapter 91. Acute Lymphoblastic Leukemia
Chapter 92. Chronic Lymphocytic Leukemia and Related Diseases
Chapter 93. Hairy Cell Leukemia
Chapter 94. Large Granular Lymphocytic Leukemia
Chapter 95. Pathology of Lymphomas
Chapter 96. The Non-Hodgkin Lymphomas
Chapter 97. Hodgkin Lymphoma
Chapter 98. Plasma Cell Neoplasms: General Considerations
Chapter 99. Essential Monoclonal Gammopathies
Chapter 100. Plasma Cell Myeloma
Chapter 101. The Amyloidoses
Chapter 102. Macroglobulinemia
Chapter 103. Heavy-Chain Diseases
Part X. Hemostasis and Thrombosis
Chapter 104. Megakaryopoiesis and Thrombopoiesis
Chapter 105. Platelet Morphology, Biochemistry, and Function
Chapter 106. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis
Chapter 107. Control of Coagulation Reactions
Chapter 108. Vascular Function in Hemostasis
Chapter 109. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis
Chapter 110. Thrombocytopenia
Chapter 111. Essential Thrombocythemia and Thrombocytosis
Chapter 112. Hereditary Qualitative Platelet Disorders
Chapter 113. Acquired Qualitative Platelet Disorders
Chapter 114. The Vascular Purpuras
Chapter 115. Hemophilia A and Hemophilia B
Chapter 116. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors
Chapter 117. Hereditary Fibrinogen Abnormalities
Chapter 118. von Willebrand Disease
Chapter 119. Antibody-Mediated Coagulation Factor Deficiencies
Chapter 120. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation
Chapter 121. Disseminated Intravascular Coagulation
Chapter 122. Hereditary Thrombophilia
Chapter 123. The Antiphospholipid Syndrome
Chapter 124. Antibody-Mediated Thrombotic Disorders: Idiopathic Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia
Chapter 125. Venous Thrombosis
Chapter 126. Atherothrombosis: Disease Initiation, Progression, and Treatment
Chapter 127. Fibrinolysis and Thrombolysis
Part XI. Transfusion Medicine
Chapter 128. Erythrocyte Antigens and Antibodies
Chapter 129. Human Leukocyte and Platelet Antigens
Chapter 130. Blood Procurement and Screening
Chapter 131. Preservation and Clinical Use of Erythrocytes and Whole Blood
Chapter 132. Preservation and Clinical Use of Platelets
Appendix 1: SI Unit Conversion Table
Color Atlas I: Red Cell Morphology
Color Atlas II: Red Cell Morphology
Color Atlas III: Red Cell Morphology
Color Atlas IV: Red Cell Morphology
Color Atlas V: Normal Erythropoiesis
Color Atlas VI: Megaloblastic Erythropoiesis
Color Atlas VII: Granulocyte and Monocyte Morphology
Color Atlas VIII: Granulocyte Morphology
Color Atlas IX: Macrophages
Color Atlas X: Normal Neutrophilopoiesis
Color Atlas XI: Normal Megakaryocytopoieis
Color Atlas XII: Abnormal Megakaryocytopoieis and Platelets
Color Atlas XIII: Normal and Abnormal Platelets
Color Atlas XIV: Marrow Sections
Color Atlas XV: Non-Hematopoietic Cells in Marrow
Color Atlas XVI: Acute Myelogenous Leukemia
Color Atlas XVII: Acute Myelogenous Leukemia
Color Atlas XVIII: Myelodysplasia
Color Atlas XIX: Chronic Myelogenous Leukemia
Color Atlas XX: Lymphocytes and Acute and Chronic Lymphocytic Leukemia
Color Atlas XXI: Plasma Cells and Myeloma
Color Atlas XXII: Lymph Node Biopsies
Color Atlas XXIII: Fluorescence In Situ Hybridization (FISH) for Cytogenetic Analysis
Color Atlas XXIV: Parasites in the Blood
Color Atlas XXV: Cutaneous Lesions
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