ABC Transporters and Multidrug Resistance
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TAMAÑO: 4.4 MB
IDIOMA: INGLES
CONTENIDO:
INTRODUCTION: WHAT IS MULTIDRUG RESISTANCE?
PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION
OF THE STRUCTURE, GENOME, NORMAL TISSUE
EXPRESSION, PHYSIOLOGICAL ASPECT, AND
MECHANISM OF ACTION
1 The P-glycoprotein 170: Just a multidrug resistance protein or a
protean molecule?
2 Multidrug resistance-associated protein (MRP/ABCC proteins)
3 ABCG2: A new challenge in cancer drug resistance
PART II ABC PROTEINS AND ONCOLOGY: EXPRESSION,
DETECTION, AND IMPLICATION OF ABC
PROTEINS IN HEMATOLOGICAL MALIGNANCIES
AND SOLID TUMORS
4 Expression, detection, and implication of ABC proteins in acute
myeloblastic leukemia
5 ABC proteins and oncology: Expression, detection, and
implication of ABC proteins in solid tumors
PART III ABC PROTEINS AND PATHOGENIC
MICROORGANISMS
6 ABC transporters and resistance to antibiotics
7 ABC proteins involved in protozoan parasite resistance
PART IV MULTIDRUG RESISTANCE (MDR) MODULATION
THROUGH INHIBITION OF ABC TRANSPORTERS:
DESIGN OF INHIBITORS AND MECHANISM
OF ACTION
8 Reversal agents for P-glycoprotein-mediated multidrug resistance
9 Reversal agents of multidrug resistance mediated by multidrug
resistance-associated proteins (MRPs)
10 Reversal agents for breast cancer resistance protein
(BCRP)-mediated multidrug resistance
11 Strategies to overcome drug resistance in acute
and chronic leukemias
12 Multidrug resistance reversal in solid tumors
PART V BIOLOGICAL AND CLINICAL ASPECTS OF
MULTIDRUG RESISTANCE: THE ROLE OF
THE TRANSPORTERS AT THE MAIN PROTECTION
BARRIERS (ABCB1, ABCC1, ABCC2, ABCG2) ON THE
BIOAVAILABILITY OF MANY TYPES
OF DRUGS AND MEDICATIONS
13 ABC superfamily transporters at the human blood–brain barrier
14 The role of ABC transporters at the intestinal barrier
15 Genetic polymorphisms in ABC transporters
